Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 7/20 | 0.37 |
| ▸ | TP53 | P04637 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263402 | 0.81 | REN (0.38) | RENTP53LMNA | |
| SCHEMBL3417109 | 0.81 | REN (0.49) | RENCYP3A4 | |
| SCHEMBL3072934 | 0.77 | REN (0.42) | RENCYP3A4 | |
| SCHEMBL3080326 | 0.73 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL3417113 | 0.72 | REN (0.41) | RENCYP3A4 | |
| SCHEMBL3259291 | 0.71 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL6234063 | 0.69 | REN (0.49) | REN | |
| SCHEMBL3065312 | 0.69 | PDE4B (0.43) | RENCYP3A4 | |
| SCHEMBL3080536 | 0.69 | REN (0.48) | REN | |
| SCHEMBL3077448 | 0.69 | REN (0.51) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790715-B2 | Organic compounds | NOVARTIS AG (CH) | 2010-09-07 | — | — | US | disclosed |