Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 9/20 | 0.64 |
| ▸ | KMO | O15229 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 3/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.42 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21835202 | 1.00 | SYK (0.64) | SYKKMOSLC6A4EGFRERBB2 | |
| SCHEMBL9873250 | 0.94 | SYK (0.64) | SYKKMOSLC6A4EGFRERBB2 | |
| SCHEMBL8306570 | 0.87 | SYK (0.54) | SYKABCB1HTR1ADRD2AURKB | |
| SCHEMBL21835286 | 0.83 | SYK (0.50) | SYKEGFRERBB2ABCB1HTR1A | |
| SCHEMBL30296587 | 0.80 | MGAM (0.47) | EGFRERBB2RAB9ASMN1; SMN2 | |
| SCHEMBL17601189 | 0.78 | SYK (1.00) | SYKKMOSLC6A4EGFRERBB2 | |
| SCHEMBL30623239 | 0.78 | SYK (1.00) | SYKKMOSLC6A4EGFRERBB2 | |
| SCHEMBL29638125 | 0.78 | SYK (0.78) | SYKKMOSLC6A4EGFRERBB2 | |
| SCHEMBL159323 | 0.78 | SYK (0.78) | SYKKMOSLC6A4EGFRERBB2 | |
| SCHEMBL27096898 | 0.78 | SYK (0.51) | SYKKMOSLC6A4EGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024026056-A2 | HETEROARYL COMPOUNDS AS EGFR INHIBITORS AND THEIR USES | ACCUTAR BIOTECHNOLOGY, INC. (US) | 2024-02-01 | — | — | WO | disclosed |