Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Pardoprunox. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 known ✓ | P14416 | 19/20 | 0.57 |
| ▸ | HTR1A known ✓ | P08908 | 15/20 | 0.57 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pardoprunox SCHEMBL1584476 | 1.00 | DRD2 (0.57) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| Pardoprunox SCHEMBL1584623 | 0.99 | DRD2 (0.56) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| Pardoprunox SCHEMBL29358670 | 0.99 | DRD2 (0.58) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| Pardoprunox SCHEMBL805311 | 0.99 | DRD2 (0.58) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| Pardoprunox SCHEMBL1584493 | 0.91 | DRD2 (0.53) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| Hydrochloric Acid SCHEMBL1886136 | 0.84 | DRD2 (0.55) | DRD2HTR1AHTR2AMCHR1 | |
| SCHEMBL13239009 | 0.84 | DRD2 (0.57) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| SCHEMBL13533093 | 0.83 | DRD2 (0.64) | DRD2HTR1AHTR2AMCHR1SLC6A4 | |
| SCHEMBL1443282 | 0.82 | DRD2 (0.56) | DRD2HTR1AHTR2AMCHR1 | |
| SCHEMBL8260753 | 0.81 | PSMB8 (0.47) | DRD2HTR1AHTR2AMCHR1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4558622-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | Trailhead Biosystems Inc. (US) | 2025-05-28 | — | — | EP | claimed |
| US-20240117303-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | TRAILHEAD BIOSYSTEMS INC. | 2024-04-11 | — | — | US | claimed |
| WO-2024019800-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | TRAILHEAD BIOSYSTEMS INC. (US) | 2024-01-25 | — | — | WO | claimed |
| EP-4558622-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | Trailhead Biosystems Inc. (US) | 2025-05-28 | — | — | EP | disclosed |
| US-20240117303-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | TRAILHEAD BIOSYSTEMS INC. | 2024-04-11 | — | — | US | disclosed |
| WO-2024019800-A1 | METHODS AND COMPOSITIONS FOR GENERATING HUMAN MIDBRAIN DOPAMINERGIC NEURONS FROM NEURAL PROGENITOR CELLS | TRAILHEAD BIOSYSTEMS INC. (US) | 2024-01-25 | — | — | WO | disclosed |