Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22554214 | 1.00 | CDK8 (0.38) | CDK8ROCK1CHEK1MAP4K4CSF1R | |
| SCHEMBL30731090 | 0.74 | NPC1 (0.44) | ALOX5APAKR1C3HTR6FEN1HRH3 | |
| SCHEMBL22554275 | 0.74 | NPC1 (0.44) | ALOX5APAKR1C3HTR6FEN1HRH3 | |
| SCHEMBL30731017 | 0.74 | NPC1 (0.44) | ALOX5APAKR1C3HTR6FEN1HRH3 | |
| SCHEMBL30730848 | 0.74 | CNR2 (0.38) | ACVR1CNR2ALOX5APAKR1C3HTR6 | |
| SCHEMBL22553813 | 0.74 | CNR2 (0.38) | ACVR1CNR2ALOX5APAKR1C3HTR6 | |
| SCHEMBL22553917 | 0.73 | ALOX5AP (0.41) | ACVR1CNR2ALOX5APAKR1C3FEN1 | |
| SCHEMBL30730773 | 0.73 | ALOX5AP (0.41) | ACVR1CNR2ALOX5APAKR1C3FEN1 | |
| SCHEMBL22553739 | 0.69 | JAK2 (0.43) | MAP4K4DYRK1ADYRK1BCNR2PIM1 | |
| SCHEMBL30730864 | 0.69 | JAK2 (0.43) | MAP4K4DYRK1ADYRK1BCNR2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | claimed |
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | disclosed |