Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | AXL | P30530 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | CLK2 | P49760 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.43 |
| ▸ | CLK3 | P49761 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | KIF20A | O95235 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22554147 | 1.00 | CHEK1 (0.49) | CHEK1LRRK2AXLCLK1CLK2 | |
| SCHEMBL19013425 | 0.74 | AXL (0.44) | CHEK1AXLCLK1CLK2CDK5 | |
| SCHEMBL857106 | 0.73 | AXL (0.47) | CHEK1AXLAURKAPARP1GPR84 | |
| SCHEMBL30322758 | 0.70 | AURKA (0.65) | CHEK1LRRK2AXLAURKAPARP1 | |
| SCHEMBL12396544 | 0.70 | AURKA (0.65) | CHEK1LRRK2AXLAURKAPARP1 | |
| SCHEMBL31710926 | 0.69 | LRRK2 (0.48) | CHEK1LRRK2AXLCLK1CLK2 | |
| SCHEMBL23885630 | 0.69 | CHEK1 (0.49) | CHEK1LRRK2CLK1CLK2CDK5 | |
| SCHEMBL21917176 | 0.69 | CHUK (0.50) | CDK5DYRK1ACDK5R1AURKAPARP1 | |
| SCHEMBL4070897 | 0.68 | AURKA (0.45) | AXLDYRK1ADYRK1BAURKAPARP1 | |
| SCHEMBL29621825 | 0.68 | AURKA (0.45) | AXLDYRK1ADYRK1BAURKAPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112088157-B | Aryl-bipyridylamine derivatives as phosphatidylinositol phosphokinase inhibitors | 拉文纳制药公司 | 2023-12-26 | — | — | CN | disclosed |