Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 8/20 | 0.50 |
| ▸ | KDM5A | P29375 | 3/20 | 0.48 |
| ▸ | KDM5C | P41229 | 1/20 | 0.48 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GABRP | O00591 | 1/20 | 0.44 |
| ▸ | GABRD | O14764 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21917178 | 0.73 | CHUK (0.50) | CHUKKDM5AKDM4EGABRPGABRD | |
| SCHEMBL27075645 | 0.70 | CHUK (0.50) | CHUKKDM5AKDM4EGABRPGABRD | |
| SCHEMBL12396541 | 0.70 | CHUK (0.78) | CHUKKDM5AKDM4EGABRPGABRD | |
| SCHEMBL30322777 | 0.70 | CHUK (0.78) | CHUKKDM5AKDM4EGABRPGABRD | |
| SCHEMBL23885176 | 0.69 | KDM5A (0.55) | CHUKKDM5AKDM5CKDM5BKDM4E | |
| SCHEMBL22554147 | 0.69 | CHEK1 (0.49) | AURKAGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL30731156 | 0.69 | CHEK1 (0.49) | AURKAGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL22871658 | 0.68 | KDM5A (0.75) | CHUKKDM5AKDM5CKDM5BKDM4E | |
| SCHEMBL3036523 | 0.68 | MAP2 (0.51) | CHUKKDM5AKDM5CKDM5BKDM4E | |
| SCHEMBL4826488 | 0.68 | CHUK (0.79) | CHUKKDM5AKDM5CKDM5BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3801499-B1 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS INC (US) | 2024-02-28 | — | — | EP | disclosed |
| US-20220194933-A1 | INHIBITORS OF SARM1 | DISARM THERAPEUTICS, INC. | 2022-06-23 | — | — | US | disclosed |
| US-20220072019-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR | DISARM THERAPEUTICS, INC. | 2022-03-10 | — | — | US | disclosed |
| US-20220008405-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NEURO-PROTECTIVE AGENTS | DISARM THERAPEUTICS, INC. | 2022-01-13 | — | — | US | disclosed |
| WO-2020132045-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NEUROPROTECTIVE AGENTS | DISARM THERAPEUTICS, INC. (US) | 2020-06-25 | — | — | WO | disclosed |
| WO-2020081923-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR | DISARM THERAPEUTICS, INC. (US) | 2020-04-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220072019-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NAD+ OR A NAD+ PRECURSOR | SARM1, NNMT, NQO1 | CHUK 2302/4885KDM5A 3518/4885KDM5C 3800/4885 |
| US-20220194933-A1 | INHIBITORS OF SARM1 | SARM1, SMN1; SMN2, SARNP | CHUK 1147/4885KDM5A 4021/4885KDM5C 3850/4885 |
| US-20220008405-A1 | INHIBITORS OF SARM1 IN COMBINATION WITH NEURO-PROTECTIVE AGENTS | SARM1, SMN1; SMN2, SARNP | CHUK 1016/4885KDM5A 4243/4885KDM5C 4244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.