SCHEMBL30733467

SCHEMBL30733467

COc1ccc(C(OC[C@H]2O[C@@H](n3ccc(=O)[nH]c3=O)C(OCC(=O)NC3CCCCCCC3)C2OP(NC(C)C)OCCC#N)(c2ccccc2)c2ccc(OC)cc2)cc1

nearest known ligand 0.33

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.33
P2RY14 Q15391 2/20 0.33
P2RY2 P41231 2/20 0.33
P2RY4 P51582 1/20 0.33
ALDH1A1 P00352 3/20 0.31
KDM4E B2RXH2 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
HPGD P15428 1/20 0.31
P2RY12 Q9H244 1/20 0.31
LMNA P02545 1/20 0.30
NPC1 O15118 1/20 0.30
RAB9A P51151 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31744971 0.92 TYMP (0.33) TYMPP2RY14P2RY2P2RY4ALDH1A1
SCHEMBL30733459 0.85 TYMP (0.33) TYMPP2RY14P2RY2P2RY4P2RY12
SCHEMBL30733463 0.83 TYMP (0.44) TYMPP2RY14P2RY2P2RY4P2RY12
SCHEMBL30733460 0.83 TYMP (0.33) TYMPP2RY14P2RY2P2RY4P2RY12
SCHEMBL13715716 0.81 TYMP (0.37) TYMPP2RY14P2RY2P2RY4P2RY12
SCHEMBL3927922 0.81 TYMP (0.37) TYMPP2RY14P2RY2P2RY4P2RY12
SCHEMBL18034334 0.80 TYMP (0.35) TYMPP2RY14P2RY2P2RY4P2RY12
SCHEMBL2520745 0.80 TYMP (0.35) TYMPP2RY14P2RY2P2RY4P2RY12
SCHEMBL30733473 0.79 TYMP (0.32) TYMPP2RY14P2RY2P2RY4
SCHEMBL31744936 0.79 TYMP (0.32) TYMPP2RY14P2RY2P2RY4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4547852-A2 MONOMERS AND METHODS FOR SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES Alnylam Pharmaceuticals, Inc. (US) 2025-05-07 EP disclosed
WO-2024006953-A2 MONOMERS AND METHODS FOR SYNTHESIS OF MODIFIED OLIGONUCLEOTIDES ALNYLAM PHARMACEUTICALS, INC. (US) 2024-01-04 WO disclosed