Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 9/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | IL1B | P01584 | 1/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.39 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 3/20 | 0.38 |
| ▸ | STAT3 | P40763 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19453082 | 0.97 | HDAC3 (0.41) | HDAC1HDAC2HDAC3NCOR2CRBN | |
| SCHEMBL26064740 | 0.89 | CRBN (0.41) | CRBNDDB1CA2MAP1LC3BBRD4 | |
| SCHEMBL27273664 | 0.89 | CRBN (0.41) | CRBNDDB1CA2MAP1LC3BBRD4 | |
| SCHEMBL20933002 | 0.85 | HDAC3 (0.43) | HDAC1HDAC2HDAC3NCOR2CRBN | |
| SCHEMBL21554525 | 0.85 | CRBN (0.42) | CRBNDDB1MAP1LC3BBRD4TNF | |
| SCHEMBL22857748 | 0.84 | CRBN (0.36) | HDAC1HDAC2HDAC3NCOR2CRBN | |
| SCHEMBL19453081 | 0.82 | CRBN (0.41) | HDAC1HDAC2HDAC3NCOR2CRBN | |
| SCHEMBL19451425 | 0.82 | CRBN (0.37) | CRBNDDB1CA2MAP1LC3BBRD4 | |
| SCHEMBL22857769 | 0.80 | CRBN (0.46) | HDAC1HDAC3CRBNDDB1MAP1LC3B | |
| SCHEMBL19541654 | 0.80 | HDAC1 (0.40) | HDAC1HDAC2CRBNDDB1MAP1LC3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519273-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | Paq Therapeutics Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023215906-A1 | KRAS G12D PROTEOLYSIS TARGETING CHIMERAS | HANGZHOU JIJING PHARMACEUTICALTECHNOLOGY LIMITED (CN) | 2023-11-09 | — | — | WO | disclosed |