Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.51 |
| ▸ | CNR2 | P34972 | 4/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CNR1 | P21554 | 3/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26639555 | 1.00 | PPARG (0.51) | PPARGCNR2PPARAMAPTCNR1 | |
| SCHEMBL26637040 | 1.00 | PPARG (0.51) | PPARGCNR2PPARAMAPTCNR1 | |
| SCHEMBL26639498 | 0.99 | PPARG (0.49) | PPARGCNR2PPARAMAPTCNR1 | |
| SCHEMBL26636436 | 0.89 | CYP4F2 (0.45) | PPARG | |
| SCHEMBL26635776 | 0.89 | CYP4F2 (0.45) | PPARG | |
| SCHEMBL30734588 | 0.89 | CYP4F2 (0.45) | PPARG | |
| SCHEMBL9470142 | 0.81 | MAPT (0.52) | PPARGCNR2PPARAMAPTCNR1 | |
| SCHEMBL30734478 | 0.79 | ALDH1A1 (0.44) | CNR2MAPTSMN1; SMN2LMNA | |
| SCHEMBL30735065 | 0.79 | ALDH1A1 (0.44) | CNR2MAPTSMN1; SMN2LMNA | |
| SCHEMBL30734973 | 0.79 | ALDH1A1 (0.44) | CNR2MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4519259-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2025-03-12 | — | — | EP | disclosed |
| WO-2023215482-A1 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. (US) | 2023-11-09 | — | — | WO | disclosed |