Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.31 |
| ▸ | CA1 | P00915 | 2/20 | 0.31 |
| ▸ | CA9 | Q16790 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14406963 | 0.77 | TP53 (0.35) | TDP1HSD17B10CA12CA1CA9 | |
| SCHEMBL3160335 | 0.72 | HSD17B10 (0.41) | HSD17B10CA12CA1CA9DDB1 | |
| SCHEMBL924527 | 0.69 | HSD17B10 (0.49) | HSD17B10L3MBTL1TP53TSHRKDM4E | |
| SCHEMBL924129 | 0.68 | HSD17B10 (0.51) | HSD17B10L3MBTL1POLBKDM4EALDH1A1 | |
| SCHEMBL19585639 | 0.66 | CRBN (0.51) | TDP1DDB1CRBNTSHRALDH1A1 | |
| SCHEMBL924794 | 0.63 | USP2 (0.40) | TDP1HSD17B10L3MBTL1POLBKDM4E | |
| SCHEMBL3174187 | 0.61 | IDH1 (0.50) | CA12CA1CA9SMN1; SMN2CA2 | |
| SCHEMBL25078428 | 0.60 | BRD4 (0.45) | — | |
| SCHEMBL480137 | 0.60 | CREBBP (0.58) | TDP1CA12CA1CA9SMN1; SMN2 | |
| SCHEMBL31702896 | 0.60 | TSHR (0.46) | CA12CA1CA9SMN1; SMN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117561258-A | Novel substituted tricyclic aza heterocycles as SOS1 inhibitors | 唯久生物技术(苏州)有限公司 | 2024-02-13 | — | — | CN | disclosed |