Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.52 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.52 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | PRKDC | P78527 | 3/20 | 0.50 |
| ▸ | DDR1 | Q08345 | 3/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20553360 | 1.00 | MTOR (0.58) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL29867929 | 1.00 | MTOR (0.58) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL30405758 | 0.93 | MTOR (0.52) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL31046941 | 0.92 | MTOR (0.48) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL21528068 | 0.92 | MTOR (0.48) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL23251625 | 0.90 | MTOR (0.62) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL23150559 | 0.89 | MTOR (0.63) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL24519483 | 0.89 | MTOR (0.61) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL29867532 | 0.89 | MTOR (0.56) | MTORHDAC1PIK3CDPIK3CAPIK3CG | |
| SCHEMBL24519503 | 0.87 | MTOR (0.57) | MTORHDAC1PIK3CDPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118978535-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-19 | — | — | CN | disclosed |
| CN-118894869-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-112771054-B | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-08-16 | — | — | CN | disclosed |
| CN-117412954-A | Synthesis of rapamycin analog compounds | 锐新医药公司 | 2024-01-16 | — | — | CN | disclosed |