Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | PRKDC | P78527 | 2/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.41 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.40 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21528068 | 1.00 | MTOR (0.48) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL29867929 | 0.92 | MTOR (0.58) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL30740011 | 0.92 | MTOR (0.58) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL20553360 | 0.92 | MTOR (0.58) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL24519417 | 0.87 | MTOR (0.47) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL23988184 | 0.86 | MTOR (0.46) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL23251851 | 0.86 | MTOR (0.46) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL23251717 | 0.86 | MTOR (0.46) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL23251690 | 0.86 | MTOR (0.46) | MTORHDAC1PIK3CAPIK3CDPIK3CG | |
| SCHEMBL30405758 | 0.85 | MTOR (0.52) | MTORHDAC1PIK3CAPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118978535-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-19 | — | — | CN | disclosed |
| CN-118894869-A | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-11-05 | — | — | CN | disclosed |
| CN-112771054-B | C40-, C28-and C32-linked rapamycin analogues as mTOR inhibitors | 锐新医药公司 | 2024-08-16 | — | — | CN | disclosed |