Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 3/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | IDH2 | P48735 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 3/20 | 0.34 |
| ▸ | IL1B | P01584 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16824579 | 1.00 | PTPN1 (0.38) | PTPN1NR1H2NR1H3CCR2FKBP1A | |
| SCHEMBL19390009 | 0.86 | HSD17B10 (0.36) | CCR2HSD17B10HDAC8CHRM2CHRM1 | |
| SCHEMBL706243 | 0.86 | PTPN1 (0.40) | PTPN1NR1H2NR1H3CCR2HSD17B10 | |
| SCHEMBL1701540 | 0.86 | PTPN1 (0.40) | PTPN1NR1H2NR1H3CCR2HSD17B10 | |
| SCHEMBL18084471 | 0.86 | HSD17B10 (0.42) | CCR2HSD17B10HDAC8CHRM2CHRM1 | |
| SCHEMBL2207075 | 0.86 | PTPN1 (0.40) | PTPN1NR1H2NR1H3CCR2HSD17B10 | |
| SCHEMBL16749487 | 0.85 | FKBP1A (0.41) | PTPN1FKBP1AHSD17B10HDAC8CHRM2 | |
| SCHEMBL17924716 | 0.85 | FKBP1A (0.41) | PTPN1FKBP1AHSD17B10HDAC8CHRM2 | |
| SCHEMBL29514248 | 0.85 | PTPN1 (0.36) | PTPN1NR1H2NR1H3CCR2FKBP1A | |
| SCHEMBL16749275 | 0.85 | FKBP1A (0.41) | PTPN1FKBP1AHSD17B10HDAC8CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4551577-A1 | FUSED RING KRAS INHIBITORS FOR TREATING DISEASE | Blossomhill Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| CN-119790058-A | Fused cyclic KRAS inhibitors for the treatment of diseases | 荣山医药股份有限公司 | 2025-04-08 | — | — | CN | disclosed |
| WO-2024015262-A1 | FUSED RING KRAS INHIBITORS FOR TREATING DISEASE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2024-01-18 | — | — | WO | disclosed |