Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | EED | O75530 | 1/20 | 0.40 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.40 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.40 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.40 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5529036 | 0.91 | RIPK1 (0.48) | RIPK1NR1H2NR1H3TSHRALDH1A1 | |
| SCHEMBL4967238 | 0.91 | RIPK1 (0.48) | RIPK1NR1H2NR1H3TSHRALDH1A1 | |
| SCHEMBL4967606 | 0.91 | RIPK1 (0.48) | RIPK1NR1H2NR1H3TSHRALDH1A1 | |
| SCHEMBL28961486 | 0.85 | NR1H2 (0.48) | RIPK1NR1H2NR1H3ALDH1A1LMNA | |
| SCHEMBL16881442 | 0.83 | RIPK1 (0.44) | RIPK1NR1H2NR1H3TSHRALDH1A1 | |
| SCHEMBL30315980 | 0.83 | RIPK1 (0.48) | RIPK1NR1H2NR1H3TSHRALDH1A1 | |
| SCHEMBL27284777 | 0.83 | NR1H2 (0.46) | RIPK1NR1H2NR1H3TSHRALDH1A1 | |
| SCHEMBL4968809 | 0.82 | RIPK1 (0.47) | RIPK1NR1H2NR1H3TSHRALDH1A1 | |
| SCHEMBL4968813 | 0.82 | RIPK1 (0.47) | RIPK1NR1H2NR1H3TSHRALDH1A1 | |
| SCHEMBL30930610 | 0.82 | NR1H2 (0.45) | RIPK1NR1H2NR1H3TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117545748-A | Benzimidazolyl GLP-1GPCR receptor agonists, pharmaceutical compositions comprising the same, and methods of use thereof | 卡莫特医疗有限公司 | 2024-02-09 | — | — | CN | disclosed |