Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MAOB | P27338 | 11/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 7/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MMP9 | P14780 | 1/20 | 0.51 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30745509 | 0.90 | MEN1 (0.56) | MEN1MAPTKMT2AMAPK1USP2 | |
| SCHEMBL30745426 | 0.90 | MAPT (0.59) | MEN1MAPTKMT2AMAPK1USP2 | |
| SCHEMBL30745507 | 0.89 | CTSL (0.59) | MEN1MAPTKMT2AMAOBLMNA | |
| SCHEMBL30745438 | 0.89 | MAOB (0.58) | MEN1MAPTKMT2AMAOBLMNA | |
| SCHEMBL30745500 | 0.82 | MEN1 (0.53) | MEN1MAPTKMT2AMAPK1USP2 | |
| SCHEMBL30745452 | 0.81 | MEN1 (0.52) | MEN1MAPTKMT2AMAPK1USP2 | |
| SCHEMBL30745443 | 0.81 | MAPT (0.52) | MEN1MAPTKMT2AMAPK1USP2 | |
| SCHEMBL30745497 | 0.81 | MAOB (0.61) | MEN1MAPTKMT2AMAPK1USP2 | |
| SCHEMBL30745454 | 0.81 | MAPT (0.57) | MEN1MAPTKMT2AMAPK1USP2 | |
| SCHEMBL7188936 | 0.78 | MEN1 (0.67) | MEN1MAPTKMT2AMAPK1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | disclosed |