Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.45 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30745496 | 0.91 | MAOB (0.53) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745473 | 0.91 | CTSL (0.53) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745408 | 0.91 | MAPT (0.54) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745443 | 0.89 | MAPT (0.52) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745472 | 0.89 | MAPT (0.60) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745494 | 0.85 | MAOB (0.48) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745489 | 0.83 | MAOB (0.47) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745498 | 0.82 | MAOB (0.53) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745465 | 0.82 | CTSL (0.54) | MAPTMAOBMEN1LMNAKMT2A | |
| SCHEMBL30745506 | 0.81 | SMN1; SMN2 (0.53) | MAPTLMNASMN1; SMN2KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | disclosed |