Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | ACHE | P22303 | 4/20 | 0.59 |
| ▸ | BACE1 | P56817 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30745463 | 0.91 | SMN1; SMN2 (0.67) | SMN1; SMN2MAPTKDM4ELMNAACHE | |
| SCHEMBL30745448 | 0.90 | SMN1; SMN2 (0.66) | SMN1; SMN2MAPTKDM4ELMNAHTT | |
| SCHEMBL30745514 | 0.90 | ACHE (0.61) | SMN1; SMN2MAPTKDM4ELMNAACHE | |
| SCHEMBL30745493 | 0.89 | ACHE (0.60) | SMN1; SMN2MAPTKDM4ELMNAACHE | |
| SCHEMBL30745403 | 0.89 | SMN1; SMN2 (0.64) | SMN1; SMN2MAPTKDM4ELMNAHTT | |
| SCHEMBL30745459 | 0.82 | MAPT (0.59) | SMN1; SMN2MAPTKDM4ELMNAACHE | |
| SCHEMBL30745412 | 0.81 | SMN1; SMN2 (0.54) | SMN1; SMN2MAPTKDM4ELMNAACHE | |
| SCHEMBL25203508 | 0.81 | SMN1; SMN2 (0.81) | SMN1; SMN2MAPTKDM4ELMNAHTT | |
| SCHEMBL30745506 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTKDM4ELMNAACHE | |
| SCHEMBL30745511 | 0.80 | SMN1; SMN2 (0.53) | SMN1; SMN2MAPTKDM4ELMNAACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | disclosed |