Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CXCL12 | P48061 | 3/20 | 0.47 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30745511 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2ABCG2MAOBARACHE | |
| SCHEMBL30745506 | 0.91 | SMN1; SMN2 (0.53) | SMN1; SMN2ACHEBACE1KDM4ELMNA | |
| SCHEMBL30745493 | 0.90 | ACHE (0.60) | SMN1; SMN2ACHEBACE1KDM4ELMNA | |
| SCHEMBL30745448 | 0.89 | SMN1; SMN2 (0.66) | SMN1; SMN2ABCG2MAOBARKDM4E | |
| SCHEMBL30745483 | 0.89 | MAOB (0.53) | SMN1; SMN2MAOBMAPT | |
| SCHEMBL30745462 | 0.85 | ABCG2 (0.47) | SMN1; SMN2ABCG2MAOBARACHE | |
| SCHEMBL30745467 | 0.84 | ABCG2 (0.46) | SMN1; SMN2ABCG2MAOBARACHE | |
| SCHEMBL30745412 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2MAOBACHEBACE1KDM4E | |
| SCHEMBL30745514 | 0.81 | ACHE (0.61) | SMN1; SMN2MAOBACHEBACE1KDM4E | |
| SCHEMBL30745496 | 0.81 | MAOB (0.53) | SMN1; SMN2ABCG2MAOBARKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | disclosed |