Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | MAOB | P27338 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.49 |
| ▸ | HIF1AN | Q9NWT6 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30745472 | 0.91 | MAPT (0.60) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL30745459 | 0.90 | MAPT (0.59) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL30745498 | 0.90 | MAOB (0.53) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL30745496 | 0.89 | MAOB (0.53) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL30745454 | 0.89 | MAPT (0.57) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL746093 | 0.85 | ABCB1 (0.63) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL30745448 | 0.82 | SMN1; SMN2 (0.66) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL30745408 | 0.81 | MAPT (0.54) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL7030422 | 0.81 | ABCB1 (0.55) | MAPTSMN1; SMN2KDM4EMAPK1HTT | |
| SCHEMBL30745453 | 0.80 | MAPT (0.53) | MAPTSMN1; SMN2KDM4EMAPK1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117567303-A | Chalcone Mannich base compound, pharmaceutical composition, preparation method and application thereof | 安徽中医药大学 | 2024-02-20 | — | — | CN | disclosed |