Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.84 |
| ▸ | KDR | P35968 | 3/20 | 0.84 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.66 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.66 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | INSR | P06213 | 1/20 | 0.66 |
| ▸ | FBP1 | P09467 | 1/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.66 |
| ▸ | FLT4 | P35916 | 1/20 | 0.66 |
| ▸ | CLK1 | P49759 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3074568 | 1.00 | EGFR (0.84) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL11727 | 0.92 | EGFR (1.00) | EGFRKDRERBB2AURKAINSR | |
| SCHEMBL6988328 | 0.91 | EGFR (0.72) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL7221386 | 0.91 | EGFR (0.72) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL3070110 | 0.90 | EGFR (0.78) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL3070116 | 0.90 | EGFR (0.78) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL10883 | 0.88 | EGFR (1.00) | EGFRKDRERBB2AURKAINSR | |
| SCHEMBL6989703 | 0.87 | EGFR (0.67) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL6991903 | 0.87 | EGFR (0.67) | EGFRKDRERBB2HDAC3HDAC4 | |
| SCHEMBL3076337 | 0.87 | EGFR (0.84) | EGFRKDRERBB2HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100267718-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | HIMMELSBACH FRANK | 2010-10-21 | — | — | US | disclosed |
| US-7196091-B2 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-03-27 | — | — | US | disclosed |
| US-20060264450-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | HIMMELSBACH FRANK | 2006-11-23 | — | — | US | disclosed |
| US-20050014772-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014772-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | RET, CYP11B1, CYP11B2 | EGFR 471/4885KDR 1302/4885ERBB2 243/4885 |
| US-20060264450-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | RET, CYP11B1, CYP11B2 | EGFR 471/4885KDR 1302/4885ERBB2 243/4885 |
| US-20100267718-A1 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them | RET, CYP11B1, CYP11B2 | EGFR 471/4885KDR 1302/4885ERBB2 243/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.