Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.76 |
| ▸ | MEN1 | O00255 | 12/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.76 |
| ▸ | RAB9A | P51151 | 11/20 | 0.76 |
| ▸ | CASP3 | P42574 | 3/20 | 0.76 |
| ▸ | SENP8 | Q96LD8 | 3/20 | 0.76 |
| ▸ | SENP7 | Q9BQF6 | 3/20 | 0.76 |
| ▸ | SENP6 | Q9GZR1 | 3/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.65 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.65 |
| ▸ | KCNN1 | Q92952 | 1/20 | 0.65 |
| ▸ | KCNN2 | Q9H2S1 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17718147 | 1.00 | NPC1 (0.76) | NPC1MEN1KMT2ARAB9ACASP3 | |
| Bromide SCHEMBL17712433 | 0.99 | NPC1 (0.78) | NPC1MEN1KMT2ARAB9ACASP3 | |
| SCHEMBL14742607 | 0.86 | MEN1 (0.81) | NPC1MEN1KMT2ARAB9ACASP3 | |
| SCHEMBL16217124 | 0.83 | MEN1 (0.83) | NPC1MEN1KMT2ARAB9ACASP3 | |
| SCHEMBL6368865 | 0.82 | KCNN1 (0.71) | NPC1MEN1KMT2ARAB9ACASP3 | |
| SCHEMBL1889546 | 0.82 | MEN1 (0.76) | NPC1MEN1KMT2ARAB9ACASP3 | |
| SCHEMBL23185367 | 0.82 | MEN1 (0.74) | NPC1MEN1KMT2ARAB9ACASP3 | |
| SCHEMBL18029498 | 0.82 | RAB9A (1.00) | NPC1MEN1KMT2ARAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6368779 | 0.81 | KCNN1 (0.70) | NPC1MEN1KMT2ARAB9ACASP3 | |
| SCHEMBL7679868 | 0.81 | MAPK1 (0.82) | NPC1MEN1KMT2ARAB9ACASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025891-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CELGENE CORPORATION | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240025891-A1 | HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES | CYP8B1, PAH, INHA | NPC1 2626/4885MEN1 2606/4885KMT2A 1911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.