Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 6/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31541392 | 0.93 | USP30 (0.54) | USP30RETCYP3A4TSHRHSD17B10 | |
| SCHEMBL182911 | 0.92 | USP30 (0.58) | USP30RETTSHRDDB1CRBN | |
| SCHEMBL30515664 | 0.92 | USP30 (0.58) | USP30RETTSHRDDB1CRBN | |
| SCHEMBL30376562 | 0.87 | USP30 (0.55) | USP30RETDDB1CRBNCYP11B2 | |
| SCHEMBL25175468 | 0.87 | USP30 (0.55) | USP30RETDDB1CRBNCYP11B2 | |
| SCHEMBL31541432 | 0.85 | HSD17B10 (0.55) | USP30CYP3A4TSHRCYP2C19HSD17B10 | |
| SCHEMBL31565394 | 0.85 | USP30 (0.45) | USP30RETCYP3A4TSHRCYP2C19 | |
| SCHEMBL31565389 | 0.85 | USP30 (0.45) | USP30RETCYP3A4TSHRCYP2C19 | |
| SCHEMBL24623333 | 0.83 | USP30 (0.58) | USP30RETDDB1CRBNGPR119 | |
| SCHEMBL31583702 | 0.82 | USP30 (0.53) | USP30RETDDB1CRBNGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4554948-A1 | TETRAHYDRONAPHTHALENE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Regents of the University of Michigan (US) | 2025-05-21 | — | — | EP | disclosed |