Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAP2K1 | Q02750 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | KIF5B | P33176 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26985119 | 1.00 | NPC1 (0.35) | NPC1KMT2ARAB9ATP53MAPT | |
| SCHEMBL26984972 | 0.78 | TP53 (0.40) | NPC1RAB9ATP53MAPTMAP2K1 | |
| SCHEMBL30746508 | 0.78 | TP53 (0.40) | NPC1RAB9ATP53MAPTMAP2K1 | |
| SCHEMBL30746672 | 0.78 | MAPK1 (0.35) | TP53MAPTMAP2K1GAAMAP2K2 | |
| SCHEMBL26984845 | 0.78 | MAPK1 (0.35) | TP53MAPTMAP2K1GAAMAP2K2 | |
| SCHEMBL30746711 | 0.76 | CYP1A2 (0.35) | NPC1KMT2ARAB9ATP53MAPT | |
| SCHEMBL26985279 | 0.76 | CYP1A2 (0.35) | NPC1KMT2ARAB9ATP53MAPT | |
| SCHEMBL26985184 | 0.72 | CLK1 (0.34) | NPC1KMT2ARAB9ATP53MAPT | |
| SCHEMBL30746457 | 0.72 | CLK1 (0.34) | NPC1KMT2ARAB9ATP53MAPT | |
| SCHEMBL30746469 | 0.71 | KMT2A (0.34) | NPC1KMT2ARAB9ATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120129678-A | Mitogen-activated protein kinase (MEK) inhibitors | 耐斯泰德医疗公司 | 2025-06-10 | — | — | CN | disclosed |
| EP-4551558-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | Nested Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |