Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | KIF5B | P33176 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.31 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.30 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.30 |
| ▸ | NQO2 | P16083 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26985184 | 1.00 | CLK1 (0.34) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL30746541 | 0.90 | SHMT2 (0.32) | MAPK1MAPTGAAL3MBTL1KMT2A | |
| SCHEMBL26984874 | 0.90 | SHMT2 (0.32) | MAPK1MAPTGAAL3MBTL1KMT2A | |
| SCHEMBL30746438 | 0.88 | NUDT1 (0.41) | EGFRKDRKMT2A | |
| SCHEMBL26984916 | 0.88 | NUDT1 (0.41) | EGFRKDRKMT2A | |
| SCHEMBL26984845 | 0.86 | MAPK1 (0.35) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL30746672 | 0.86 | MAPK1 (0.35) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL30746469 | 0.83 | KMT2A (0.34) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL26984886 | 0.83 | KMT2A (0.34) | CLK1MAPK1TP53MAPTRET | |
| SCHEMBL26994476 | 0.82 | CLK1 (0.33) | CLK1MAPK1TP53MAPTRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-120129678-A | Mitogen-activated protein kinase (MEK) inhibitors | 耐斯泰德医疗公司 | 2025-06-10 | — | — | CN | disclosed |
| EP-4551558-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | Nested Therapeutics, Inc. (US) | 2025-05-14 | — | — | EP | disclosed |
| WO-2024010925-A2 | MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |