Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 11/20 | 0.39 |
| ▸ | HTR2B | P41595 | 11/20 | 0.39 |
| ▸ | HTR2A | P28223 | 10/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.37 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30747194 | 0.89 | PARP1 (0.46) | PARP1HTR2CHTR2BHTR2ACRBN | |
| SCHEMBL30069799 | 0.89 | PARP1 (0.46) | PARP1HTR2CHTR2BHTR2ACRBN | |
| SCHEMBL30595369 | 0.84 | PARP1 (0.42) | PARP1HTR2CHTR2BHTR2ACRBN | |
| SCHEMBL27376597 | 0.82 | CRBN (0.42) | CRBNMAP3K5ITGB3ITGA2B | |
| SCHEMBL30747080 | 0.81 | HTR2C (0.41) | PARP1HTR2CHTR2BHTR2ACRBN | |
| SCHEMBL29966331 | 0.81 | PARP1 (0.46) | PARP1HTR2CHTR2BHTR2AHTR3E | |
| SCHEMBL29966514 | 0.81 | PARP1 (0.46) | PARP1HTR2CHTR2BHTR2AHTR3E | |
| SCHEMBL26625271 | 0.81 | PARP1 (0.46) | PARP1HTR2CHTR2BHTR2AHTR3E | |
| SCHEMBL30695894 | 0.79 | HTR2C (0.49) | PARP1HTR2CHTR2BHTR2ACRBN | |
| SCHEMBL5863984 | 0.79 | HTR6 (0.42) | HTR2CHTR2BHTR2ACRBNITGB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522621-A1 | 6,6A,7,8,9,10-HEXAHYDRO-5H-PYRAZINO[1',2':4,5]PYRAZINO[2,3-C]PYRIDAZINE DERIVATIVES AS SMARCA4 PROTEIN DEGRADERS FOR THE TREATMENT OF CANCER | Prelude Therapeutics Incorporated (US) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220577-A1 | 6,6A,7,8,9,10-HEXAHYDRO-5H-PYRAZINO[1',2':4,5]PYRAZINO[2,3-C]PYRIDAZINE DERIVATIVES AS SMARCA4 PROTEIN DEGRADERS FOR THE TREATMENT OF CANCER | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2023-11-16 | — | — | WO | disclosed |