Pudafensine

Pudafensine

SCHEMBL30747225

COc1cc2ccc(OC3CC4CCC(C3)N4)cc2oc1=O

nearest known ligand 0.71

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 13/20 0.61
SLC6A2 P23975 10/20 0.61
SLC6A3 Q01959 10/20 0.61
MAOB P27338 2/20 0.46
MAOA P21397 1/20 0.43
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
POLB P06746 1/20 0.42
CYP3A4 P08684 1/20 0.42
MAPT P10636 1/20 0.42
HPGD P15428 1/20 0.42
DPP4 P27487 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TDP1 Q9NUW8 1/20 0.42
MCL1 Q07820 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pudafensine SCHEMBL2316742 1.00 SLC6A4 (0.61) SLC6A4SLC6A2SLC6A3MAOBMAOA
Pudafensine SCHEMBL26989874 1.00 SLC6A4 (0.61) SLC6A4SLC6A2SLC6A3MAOBMAOA
Pudafensine SCHEMBL30747230 1.00 SLC6A4 (0.61) SLC6A4SLC6A2SLC6A3MAOBMAOA
Pudafensine SCHEMBL30747224 1.00 SLC6A4 (0.61) SLC6A4SLC6A2SLC6A3MAOBMAOA
Pudafensine SCHEMBL2316862 0.99 SLC6A4 (0.60) SLC6A4SLC6A2SLC6A3MAOBMAOA
Pudafensine SCHEMBL30747233 0.99 SLC6A4 (0.60) SLC6A4SLC6A2SLC6A3MAOBMAOA
SCHEMBL246579 0.88 SLC6A4 (0.58) SLC6A4SLC6A2SLC6A3MAOBMAOA
Hydrochloric Acid SCHEMBL248642 0.87 SLC6A4 (0.57) SLC6A4SLC6A2SLC6A3MAOBMAOA
SCHEMBL15304588 0.86 SLC6A4 (0.82) SLC6A4SLC6A2SLC6A3MAOBMAOA
SCHEMBL742602 0.86 SLC6A4 (0.82) SLC6A4SLC6A2SLC6A3MAOBMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4646204-A1 COMPOUND FOR TREATMENT OF ERECTILE DYSFUNCTION Initiator Pharma A/S (DK) 2025-11-12 EP disclosed
EP-4551221-A1 COMPOUND FOR TREATMENT OF FEMALE SEXUAL DYSFUNCTION Initiator Pharma A/S (DK) 2025-05-14 EP disclosed
WO-2024146892-A1 COMPOUND FOR TREATMENT OF ERECTILE DYSFUNCTION INITIATOR PHARMA A/S (DK) 2024-07-11 WO disclosed
WO-2024008808-A1 COMPOUND FOR TREATMENT OF FEMALE SEXUAL DYSFUNCTION INITIATOR PHARMA A/S (DK) 2024-01-11 WO disclosed