Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.30 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56742 | 0.94 | — | — | |
| SCHEMBL30087352 | 0.94 | TSHR (0.41) | USP2TSHRALDH1A1LMNACYP1A2 | |
| SCHEMBL17288070 | 0.94 | TSHR (0.41) | USP2TSHRALDH1A1LMNACYP1A2 | |
| SCHEMBL491716 | 0.94 | TSHR (0.41) | USP2TSHRALDH1A1LMNACYP1A2 | |
| SCHEMBL3043105 | 0.94 | TSHR (0.41) | USP2TSHRALDH1A1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL12483735 | 0.92 | USP2 (0.39) | USP2TSHRALDH1A1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL8788527 | 0.92 | USP2 (0.39) | USP2TSHRALDH1A1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL491971 | 0.92 | USP2 (0.39) | USP2TSHRALDH1A1LMNACYP1A2 | |
| Hydrochloric Acid SCHEMBL57599 | 0.92 | USP2 (0.39) | USP2TSHRALDH1A1LMNACYP1A2 | |
| SCHEMBL944236 | 0.91 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790717-B2 | administering 3-(4'-Morpholin-4-ylmethyl-biphenyl-4-ylmethyl)-1-oxa-3-aza-spiro[4.5]decan-2-one, for the treatment of schizophrenia | ASTRAZENECA AB (SE) | 2010-09-07 | — | — | US | disclosed |
| EP-2061775-A2 | SPIRO-OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | Astra Zeneca AB (SE) | 2009-05-27 | — | — | EP | disclosed |
| US-20090124578-A1 | SPIRO-OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (SE) | 2009-05-14 | — | — | US | disclosed |
| US-7485722-B2 | Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA AB (SE) | 2009-02-03 | — | — | US | disclosed |
| US-20080125431-A1 | Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators | ASTRAZENECA (SE) | 2008-05-29 | — | — | US | disclosed |
| WO-2008032191-A2 | SPIRO-OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | ASTRAZENECA AB (US) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090124578-A1 | SPIRO-OXAZOLIDINONE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR POTENTIATORS | GRM1, GRIN1, GRM2 | SLC6A3 526/4885USP2 4821/4885TSHR 476/4885 |
| US-20080125431-A1 | Spiro-oxazolidinone compounds and their use as metabotropic glutamate receptor potentiators | GRM1, GRIN1, GRM2 | SLC6A3 526/4885USP2 4821/4885TSHR 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.