SCHEMBL30747732

SCHEMBL30747732

[2H]c1cc(=O)[nH]c2ncncc12

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PDE3B Q13370 1/20 0.37
PDE3A Q14432 1/20 0.37
KDM4E B2RXH2 1/20 0.34
ALDH1A1 P00352 1/20 0.34
LMNA P02545 1/20 0.34
GLA P06280 1/20 0.34
PMP22 Q01453 1/20 0.34
HSD17B10 Q99714 1/20 0.34
EGFR P00533 5/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL217007 0.83 PDE3B (0.48) PDE3BPDE3AKDM4EALDH1A1LMNA
SCHEMBL29362624 0.83 PDE3B (0.48) PDE3BPDE3AKDM4EALDH1A1LMNA
Hydrochloric Acid SCHEMBL6225226 0.81 PDE3B (0.47) PDE3BPDE3AKDM4EALDH1A1LMNA
Hydrochloric Acid SCHEMBL29546568 0.81 PDE3B (0.47) PDE3BPDE3AKDM4EALDH1A1LMNA
Hydrochloric Acid SCHEMBL30718276 0.81 PDE3B (0.47) PDE3BPDE3AKDM4EALDH1A1LMNA
Trifluoroacetic Acid SCHEMBL28810979 0.71 PDE3B (0.38) PDE3BPDE3AKDM4EALDH1A1LMNA
SCHEMBL30542328 0.69
SCHEMBL30375316 0.69 EGFR (0.33) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL1270307 0.69 EGFR (0.33) KDM4EALDH1A1LMNAGLAPMP22
SCHEMBL16266562 0.67 EGFR (0.32) EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117430599-A Cyclin dependent kinase inhibitors 南京再明医药有限公司 2024-01-23 CN disclosed