Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | F11 | P03951 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29362624 | 0.86 | PDE3B (0.48) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| SCHEMBL217007 | 0.86 | PDE3B (0.48) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL29546568 | 0.84 | PDE3B (0.47) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL6225226 | 0.84 | PDE3B (0.47) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| Hydrochloric Acid SCHEMBL30718276 | 0.84 | PDE3B (0.47) | PDE3BPDE3AMAPK8MAPK9MAPK10 | |
| Trifluoroacetic Acid SCHEMBL3278943 | 0.81 | HRH4 (0.35) | HRH4HRH3L3MBTL1PAX8 | |
| Trifluoroacetic Acid SCHEMBL28780341 | 0.79 | RIPK1 (0.40) | HRH4HRH3MAPK8SYKCDK5 | |
| Trifluoroacetic Acid SCHEMBL28264177 | 0.75 | BACE1 (0.37) | HRH4HRH3L3MBTL1PAX8AR | |
| SCHEMBL29363004 | 0.73 | PDE3B (0.36) | PDE3BPDE3AKDM4EALDH1A1LMNA | |
| Trifluoroacetic Acid SCHEMBL28330487 | 0.73 | ABL1 (0.34) | HRH4HRH3L3MBTL1PAX8NR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116425742-A | Bicyclic heteroaryl compounds and uses thereof | 锐新医药公司 | 2023-07-14 | — | — | CN | disclosed |
| EP-4065578-A1 | FUSED PYRIMIDINE PYRIDINONE COMPOUNDS AS JAK INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2022-10-05 | — | — | EP | disclosed |
| CN-114901662-A | Bicyclic heteroaryl compounds and uses thereof | 锐新医药公司 | 2022-08-12 | — | — | CN | disclosed |