Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.54 |
| ▸ | BTK | Q06187 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 8/20 | 0.49 |
| ▸ | ULK1 | O75385 | 1/20 | 0.48 |
| ▸ | TTK | P33981 | 1/20 | 0.47 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25002783 | 1.00 | EGFR (0.54) | EGFRBTKLRRK2ULK1TTK | |
| SCHEMBL25002778 | 1.00 | EGFR (0.54) | EGFRBTKLRRK2ULK1TTK | |
| SCHEMBL30748506 | 1.00 | EGFR (0.54) | EGFRBTKLRRK2ULK1TTK | |
| SCHEMBL25001527 | 0.92 | EGFR (0.55) | EGFRBTKLRRK2TTKALK | |
| SCHEMBL23442652 | 0.90 | EGFR (0.66) | EGFRBTKLRRK2TTKALK | |
| SCHEMBL25001890 | 0.90 | EGFR (0.55) | EGFRBTKTTK | |
| SCHEMBL25002059 | 0.89 | EGFR (0.61) | EGFRBTK | |
| SCHEMBL25002777 | 0.89 | EGFR (0.61) | EGFRBTK | |
| SCHEMBL25002792 | 0.89 | EGFR (0.54) | EGFRBTKLRRK2TTKALK | |
| SCHEMBL25001899 | 0.89 | EGFR (0.57) | EGFRBTKTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112538072-B | Aminopyrimidine EGFR inhibitors | 齐鲁制药有限公司 | 2024-02-06 | — | — | CN | disclosed |