SCHEMBL30748807

SCHEMBL30748807

O=C1C(F)CC(C(F)(F)F)N1Cc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 14/20 0.47
HCRTR2 O43614 14/20 0.47
EHMT2 Q96KQ7 1/20 0.46
CYP3A4 P08684 2/20 0.43
TSHR P16473 2/20 0.43
CYP2C19 P33261 1/20 0.43
ALDH1A1 P00352 3/20 0.41
SMN1; SMN2 Q16637 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30749017 1.00 HCRTR1 (0.47) HCRTR1HCRTR2EHMT2CYP3A4TSHR
SCHEMBL30748923 0.74 HCRTR2 (0.47) HCRTR1HCRTR2EHMT2
SCHEMBL30748727 0.74 HCRTR2 (0.47) HCRTR1HCRTR2EHMT2
SCHEMBL8592117 0.73 HCRTR1 (0.44) HCRTR1HCRTR2EHMT2CYP3A4TSHR
Hydrochloric Acid SCHEMBL8591197 0.72 HCRTR1 (0.43) HCRTR1HCRTR2EHMT2CYP3A4TSHR
SCHEMBL30748759 0.69 MAPT (0.42)
SCHEMBL30748816 0.69 MAPT (0.42)
SCHEMBL8997506 0.68 MAPT (0.44) ALDH1A1
SCHEMBL32685260 0.67 TSHR (0.46) EHMT2TSHRCYP2C19ALDH1A1SMN1; SMN2
SCHEMBL11776300 0.66 EHMT2 (0.58) HCRTR1HCRTR2EHMT2CYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4565588-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF Suzhou Keen Therapeutics Co., Ltd. (CN) 2025-06-11 EP disclosed
WO-2023241620-A1 BIOLOGICALLY ACTIVE COMPOUNDS AND METHODS THEREOF SUZHOU KEEN THERAPEUTICS CO., LTD. (CN) 2023-12-21 WO disclosed