Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582790 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KDM4EOPRK1CHRM1RECQL | |
| SCHEMBL3076755 | 1.00 | ALDH1A1 (0.48) | ALDH1A1KDM4EOPRK1CHRM1RECQL | |
| SCHEMBL581848 | 0.90 | ALDH1A1 (0.39) | ALDH1A1KDM4EOPRK1CHRM1RECQL | |
| SCHEMBL581046 | 0.90 | ALDH1A1 (0.39) | ALDH1A1KDM4EOPRK1CHRM1RECQL | |
| SCHEMBL3069038 | 0.90 | ALDH1A1 (0.39) | ALDH1A1KDM4EOPRK1CHRM1RECQL | |
| SCHEMBL582479 | 0.90 | EPHX2 (0.43) | ALDH1A1KDM4EOPRK1MEN1KMT2A | |
| SCHEMBL581386 | 0.90 | EPHX2 (0.43) | ALDH1A1KDM4EOPRK1MEN1KMT2A | |
| SCHEMBL581385 | 0.90 | EPHX2 (0.43) | ALDH1A1KDM4EOPRK1MEN1KMT2A | |
| SCHEMBL582086 | 0.89 | PPARG (0.40) | ALDH1A1KDM4ECHRM1RECQLTSHR | |
| SCHEMBL3075705 | 0.89 | PPARG (0.40) | ALDH1A1KDM4ECHRM1RECQLTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415378-B2 | Isoxazol-3(2H)-one analogs as therapeutic agents | ASTRAZENECA AB (SE) | 2013-04-09 | — | — | US | disclosed |
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | NR4A3, CBR3, OXER1 | ALDH1A1 2598/4885KDM4E 2668/4885OPRK1 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.