Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CTSD | P07339 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13101623 | 0.91 | SMN1; SMN2 (0.52) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL13102375 | 0.91 | SMN1; SMN2 (0.45) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL13101617 | 0.90 | SMN1; SMN2 (0.47) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL13101624 | 0.88 | CCNA2 (0.45) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL13101615 | 0.88 | SMN1; SMN2 (0.44) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL14539654 | 0.88 | KDM4E (0.44) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL13102313 | 0.87 | ALDH1A1 (0.50) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL13101630 | 0.87 | SMN1; SMN2 (0.45) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL13102436 | 0.86 | TSHR (0.49) | ALDH1A1ATMTSHRKDM4EMAPK1 | |
| SCHEMBL13102248 | 0.84 | SMN1; SMN2 (0.45) | ALDH1A1ATMTSHRKDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663237-B1 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN INC (US) | 2013-06-19 | — | — | EP | disclosed |
| US-8329713-B2 | Fused ring heterocycles as potassium channel modulators | ICAGEN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-8329713-B2 | Fused ring heterocycles as potassium channel modulators | ICAGEN INC. (US) | 2012-12-11 | — | — | US | disclosed |
| US-20100273784-A1 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2010-10-28 | — | — | US | disclosed |
| US-20100273784-A1 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2010-10-28 | — | — | US | disclosed |
| US-7741332-B2 | Fused ring heterocycles as potassium channel modulators | ICAGEN, INC. (US) | 2010-06-22 | — | — | US | disclosed |
| EP-1663237-A4 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN INC (US) | 2009-04-29 | — | — | EP | disclosed |
| US-20080058319-A1 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2008-03-06 | — | — | US | disclosed |
| US-7223768-B2 | Fused ring heterocycles as potassium channel modulators | ICAGEN, INC. (US) | 2007-05-29 | — | — | US | disclosed |
| EP-1663237-A2 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | Icagen, Inc. (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005025293-A2 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | ICAGEN, INC. (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20050059823-A1 | Fused ring heterocycles as potassium channel modulators | ICAGEN, INC. (US) | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080058319-A1 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | KCNK17, KCNJ2, KCNJ1 | ALDH1A1 2354/4885ATM 1284/4885TSHR 1918/4885 |
| US-20100273784-A1 | FUSED RING HETEROCYCLES AS POTASSIUM CHANNEL MODULATORS | KCNK17, KCNJ2, KCNJ1 | ALDH1A1 2354/4885ATM 1284/4885TSHR 1918/4885 |
| US-20050059823-A1 | Fused ring heterocycles as potassium channel modulators | KCNK17, KCNJ2, KCNJ1 | ALDH1A1 2354/4885ATM 1284/4885TSHR 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.