SCHEMBL30749484

SCHEMBL30749484

O=C(OC1=CC(=O)c2ccccc2C1=O)c1ccc(F)cc1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
S100A4 P26447 1/20 0.74
CDC25B P30305 3/20 0.53
CDC25A P30304 2/20 0.53
IDO1 P14902 1/20 0.53
CES2 O00748 1/20 0.49
CES1 P23141 1/20 0.49
GAPDH P04406 2/20 0.46
MAPT P10636 5/20 0.44
CASP3 P42574 2/20 0.44
SENP8 Q96LD8 2/20 0.44
SENP7 Q9BQF6 2/20 0.44
SENP6 Q9GZR1 2/20 0.44
CYP19A1 P11511 1/20 0.43
NPC1 O15118 1/20 0.42
PKM P14618 1/20 0.42
RAB9A P51151 1/20 0.42
PTPN1 P18031 2/20 0.42
PTPRC P08575 1/20 0.42
PTPRF P10586 1/20 0.42
LMNA P02545 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29209310 1.00 S100A4 (0.74) S100A4CDC25BCDC25AIDO1CES2
SCHEMBL30749477 0.88 S100A4 (0.78) S100A4CDC25BCDC25AIDO1CES2
SCHEMBL8142691 0.88 S100A4 (0.78) S100A4CDC25BCDC25AIDO1CES2
SCHEMBL2599357 0.85 S100A4 (1.00) S100A4CDC25BCDC25AIDO1CES2
SCHEMBL29209303 0.83 S100A4 (0.75) S100A4CDC25BCDC25AIDO1CES2
SCHEMBL30749480 0.83 S100A4 (0.75) S100A4CDC25BCDC25AIDO1CES2
SCHEMBL13144212 0.79 S100A4 (0.68) S100A4CDC25BCDC25AIDO1GAPDH
SCHEMBL30106703 0.76 MAPT (0.56) S100A4CDC25BCES2CES1MAPT
SCHEMBL29209301 0.76 S100A4 (0.57) S100A4CDC25BCDC25AIDO1CES2
SCHEMBL14197455 0.75 S100A4 (0.47) S100A4MAPTCASP3SENP7NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117510338-A Natural naphthoquinone derivative and preparation method and application thereof 贵州大学 2024-02-06 CN claimed
CN-117510338-A Natural naphthoquinone derivative and preparation method and application thereof 贵州大学 2024-02-06 CN disclosed