Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 15/20 | 0.45 |
| ▸ | JAK1 | P23458 | 13/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | CDK2 | P24941 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30751560 | 0.92 | PTPN11 (0.45) | TYK2JAK1CYP2C19PTPN11KCNH2 | |
| SCHEMBL30751564 | 0.90 | TYK2 (0.46) | TYK2JAK1CYP2C19PTPN11KCNH2 | |
| SCHEMBL30751548 | 0.86 | TYK2 (0.46) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL30751495 | 0.84 | PTPN11 (0.52) | TYK2JAK1PTPN11ALKCKS1B | |
| Hydrochloric Acid SCHEMBL30751559 | 0.83 | TYK2 (0.46) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL30751502 | 0.82 | SYK (0.45) | TYK2JAK1CYP2C19PTPN11 | |
| SCHEMBL30751500 | 0.81 | TYK2 (0.53) | TYK2JAK1CYP2C19KCNH2JAK2 | |
| SCHEMBL30751534 | 0.81 | PTPN11 (0.51) | TYK2JAK1PTPN11KCNH2CKS1B | |
| SCHEMBL30751557 | 0.80 | TYK2 (0.54) | TYK2JAK1CYP2C19KCNH2 | |
| SCHEMBL30751501 | 0.79 | TYK2 (0.53) | TYK2JAK1CYP2C19KCNH2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250257051-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS TYK2 INHIBITORS | 1910 GENETICS INC (US) | 2025-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250257051-A1 | SUBSTITUTED PYRIMIDINE COMPOUNDS AS TYK2 INHIBITORS | TYK2, PDXK, JAK1 | TYK2 1/4885JAK1 3/4885CYP2C19 680/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.