Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.34 |
| ▸ | PGK1 | P00558 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26696689 | 0.83 | TRPV4 (0.39) | ALDH1A1TRPV4KHKVCAM1CYP11B2 | |
| SCHEMBL5843414 | 0.78 | TRPV4 (0.38) | ALDH1A1TRPV4VCAM1PGK1 | |
| SCHEMBL147827 | 0.78 | TRPV4 (0.43) | TRPV4KHKCYP11B2CYP11B1 | |
| SCHEMBL5842498 | 0.75 | TSHR (0.35) | TRPV4CYP11B2ARCYP11B1 | |
| SCHEMBL5843925 | 0.75 | TRPV4 (0.32) | TRPV4AR | |
| SCHEMBL5843265 | 0.75 | KHK (0.35) | TRPV4KHKCYP11B2CYP11B1 | |
| SCHEMBL27988403 | 0.75 | AR (0.36) | ALDH1A1TRPV4VCAM1PGK1AR | |
| SCHEMBL6747562 | 0.74 | TRPV4 (0.43) | TRPV4KHKCYP11B2CYP11B1 | |
| SCHEMBL442153 | 0.72 | — | — | |
| SCHEMBL5843854 | 0.72 | AR (0.40) | TRPV4AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100227846-A1 | SUBSTITUTED PYRAZOLE DERIVATIVE | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-09-09 | — | — | US | disclosed |
| EP-2194045-A1 | SUBSTITUTED PYRAZOLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2010-06-09 | — | — | EP | disclosed |
| US-20090270359-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-10-29 | — | — | US | disclosed |
| US-7012041-B2 | Phenylpyridazinones | BAYER AG (DE) | 2006-03-14 | — | — | US | disclosed |
| EP-1120411-B1 | 4-Aryl-1,2,4-triazolidinedione derivatives and their use as herbicides | BAYER CROPSCIENCE AG (DE) | 2004-09-22 | — | — | EP | disclosed |
| US-6743755-B2 | HERBICIDAL COMPOSITION WHICH HAS A CONTENT OF AT LEAST ONE N-ARYL NITROGEN-CONTAINING HETEROCYCLIC COMPOUND OF THE GENERAL METHOD OF COMBATING UNDESIRABLE PLANTS WHICH COMPRISES ALLOWING AN N-ARYL NITROGEN-CONTAINING HETEROCYCLIC | BAYER AKTIENGESELLSCHAFT (DE) | 2004-06-01 | — | — | US | disclosed |
| US-20030208073-A1 | Substituted N-aryl nitrogen-containing heterocyclic compounds | LINKER KARL-HEINZ (DE) | 2003-11-06 | — | — | US | disclosed |
| EP-0832072-B1 | PHENYLPYRIDAZINONES | BAYER CROPSCIENCE AG (DE) | 2003-09-24 | — | — | EP | disclosed |
| US-20030119673-A1 | Phenylpyridazinones | LINKER KARL-HEINZ (DE) | 2003-06-26 | — | — | US | disclosed |
| US-6551963-B1 | For controlling unwanted vegetation | BAYER AKTIENGESELLSCHAFT (DE) | 2003-04-22 | — | — | US | disclosed |
| WO-2000008000-A1 | USE OF SUBSTITUTED TRIAZINONES AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2000-02-17 | — | — | WO | disclosed |
| WO-1999052878-A1 | SUBSTITUTED PHENYL PYRIDAZINONES | BAYER AKTIENGESELLSCHAFT (DE) | 1999-10-21 | — | — | WO | disclosed |
| EP-0882027-A1 | SUBSTITUTED 2-ARYL-1,2,4-TRIAZINE-3,5-DI(THI)ONES AS HERBICIDES | BAYER AG (DE) | 1998-12-09 | — | — | EP | disclosed |
| EP-0832072-A1 | PHENYLPYRIDAZINONES | BAYER AG (DE) | 1998-04-01 | — | — | EP | disclosed |
| EP-0797573-A1 | 3-ARYL-1,2,4-TRIAZOLE DERIVATIVES WITH HERBICIDAL PROPERTIES | BAYER AG (DE) | 1997-10-01 | — | — | EP | disclosed |
| WO-1997030980-A1 | SUBSTITUTED 2-ARYL-1,2,4-TRIAZINE-3,5-DI(THI)ONES AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-08-28 | — | — | WO | disclosed |
| WO-1997026248-A1 | SUBSTITUTED N-ARYL NITROGEN HETEROCYCLIC COMPOUNDS AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-24 | — | — | WO | disclosed |
| WO-1997005117-A1 | SUBSTITUTED 1-PHENYLURACIL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-02-13 | — | — | WO | disclosed |
| WO-1996039392-A1 | PHENYLPYRIDAZINONES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-12 | — | — | WO | disclosed |
| WO-1996018618-A1 | 3-ARYL-1,2,4-TRIAZOLE DERIVATIVES WITH HERBICIDAL PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227846-A1 | SUBSTITUTED PYRAZOLE DERIVATIVE | AR, NR5A1, NR3C2 | ALDH1A1 809/4885TRPV4 1436/4885KHK 2976/4885 |
| US-20030208073-A1 | Substituted N-aryl nitrogen-containing heterocyclic compounds | NAT1, CYP1B1, CYP1A1 | ALDH1A1 138/4885TRPV4 3908/4885KHK 2436/4885 |
| US-20030119673-A1 | Phenylpyridazinones | CYP2D6, CYP1A1, CYP1B1 | ALDH1A1 35/4885TRPV4 3210/4885KHK 1062/4885 |
| US-20090270359-A1 | SUBSTITUTED PYRAZOLE DERIVATIVES | AR, NR5A1, NR3C2 | ALDH1A1 816/4885TRPV4 1405/4885KHK 3025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.