Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | TACR1 | P25103 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL582055 | 1.00 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2TACR1KMT2ATSHR | |
| SCHEMBL581695 | 1.00 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2TACR1KMT2ATSHR | |
| SCHEMBL581270 | 0.89 | PPARG (0.43) | ALDH1A1SMN1; SMN2TACR1KMT2APOLB | |
| SCHEMBL582387 | 0.89 | PPARG (0.43) | ALDH1A1SMN1; SMN2TACR1KMT2APOLB | |
| SCHEMBL3074992 | 0.89 | PPARG (0.43) | ALDH1A1SMN1; SMN2TACR1KMT2APOLB | |
| SCHEMBL3083072 | 0.88 | KMT2A (0.41) | ALDH1A1KMT2APOLBLMNAMEN1 | |
| SCHEMBL580881 | 0.88 | KMT2A (0.41) | ALDH1A1KMT2APOLBLMNAMEN1 | |
| SCHEMBL582368 | 0.88 | KMT2A (0.41) | ALDH1A1KMT2APOLBLMNAMEN1 | |
| SCHEMBL581857 | 0.88 | CYP3A4 (0.38) | ALDH1A1SMN1; SMN2TACR1TSHRHTT | |
| SCHEMBL581858 | 0.88 | CYP3A4 (0.38) | ALDH1A1SMN1; SMN2TACR1TSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415378-B2 | Isoxazol-3(2H)-one analogs as therapeutic agents | ASTRAZENECA AB (SE) | 2013-04-09 | — | — | US | disclosed |
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261755-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | NR4A3, CBR3, OXER1 | ALDH1A1 2598/4885SMN1; SMN2 2619/4885TACR1 474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.