Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 9/20 | 0.44 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.44 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | MGLL | Q99685 | 1/20 | 0.32 |
| ▸ | FPR3 | P25089 | 1/20 | 0.32 |
| ▸ | FPR2 | P25090 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27386026 | 0.80 | PRMT5 (0.50) | PRMT5WDR77PARP1GFERKDM4E | |
| SCHEMBL30752865 | 0.80 | PRMT5 (0.50) | PRMT5WDR77PARP1GFERKDM4E | |
| SCHEMBL27385996 | 0.78 | PRMT5 (0.48) | PRMT5WDR77PARP1GFERKDM4E | |
| SCHEMBL23087948 | 0.74 | PRMT5 (0.66) | PRMT5WDR77PARP1KDM4ELMNA | |
| SCHEMBL31376007 | 0.74 | PRMT5 (0.56) | PRMT5WDR77PARP1GFERKDM4E | |
| SCHEMBL31375967 | 0.74 | PRMT5 (0.43) | PRMT5WDR77PARP1GFERKDM4E | |
| SCHEMBL25581154 | 0.73 | PRMT5 (0.51) | PRMT5WDR77PARP1GFERIGF1R | |
| SCHEMBL30430242 | 0.73 | PRMT5 (0.51) | PRMT5WDR77PARP1GFERIGF1R | |
| SCHEMBL31376006 | 0.71 | PRMT5 (0.51) | PRMT5WDR77PARP1GFERKDM4E | |
| SCHEMBL30753025 | 0.70 | PRMT5 (0.47) | PRMT5WDR77PARP1GFERIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024027703-A1 | PRMT5 INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 上海艾力斯医药科技股份有限公司 | 2024-02-08 | — | — | WO | disclosed |