Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3093871 | 0.85 | ADORA3 (0.53) | HSP90AA1ADORA3HSP90AB1ADORA2AADORA1 | |
| SCHEMBL3087861 | 0.73 | ADORA3 (0.65) | HSP90AA1ADORA3HSP90AB1ADORA2AADORA1 | |
| SCHEMBL3099110 | 0.73 | KCNH2 (0.53) | HSP90AA1ADORA3KCNH2NPC1ALDH1A1 | |
| SCHEMBL3075309 | 0.72 | NPC1 (0.56) | HSP90AA1ADORA3ADORA2AADORA1NPC1 | |
| SCHEMBL3093712 | 0.71 | HSP90AA1 (0.51) | HSP90AA1ADORA3ADORA2AADORA1KCNH2 | |
| SCHEMBL3088463 | 0.70 | HSP90AA1 (0.53) | HSP90AA1ADORA3ADORA2AKCNH2PKM | |
| SCHEMBL3075302 | 0.68 | HSP90AA1 (0.51) | HSP90AA1ADORA3ADORA2AADORA1MEN1 | |
| SCHEMBL13144854 | 0.68 | HSP90AA1 (0.50) | HSP90AA1ADORA3ADORA2AKCNH2PKM | |
| SCHEMBL16628739 | 0.68 | IP6K1 (0.44) | HSP90AA1ADORA3HSP90AB1ALDH1A1MAPT | |
| SCHEMBL3093720 | 0.67 | HSP90AA1 (0.49) | HSP90AA1ADORA3ADORA2AKCNH2PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164833-B1 | Quinazolinamide derivatives useful for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2015-04-15 | — | — | EP | claimed |
| US-8501754-B2 | Quinazolinamide derivatives | MERCK PATENT GMBH (DE) | 2013-08-06 | — | — | US | claimed |
| US-20100234324-A1 | Quinazolinamide derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2010-09-16 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100234324-A1 | Quinazolinamide derivatives | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885ADORA3 3301/4885HSP90AB1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.