Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.56 |
| ▸ | DRD3 | P35462 | 8/20 | 0.49 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3963444 | 1.00 | DRD2 (0.56) | DRD2DRD3KCNA3AAK1HTR2A | |
| SCHEMBL3067525 | 0.90 | DRD3 (0.53) | DRD2DRD3HTR2AHRH1CCR3 | |
| SCHEMBL3078178 | 0.90 | DRD3 (0.53) | DRD2DRD3HTR2AHRH1CCR3 | |
| SCHEMBL3075416 | 0.89 | DRD2 (0.53) | DRD2DRD3KCNA3HTR2AHRH1 | |
| SCHEMBL3962394 | 0.89 | DRD2 (0.53) | DRD2DRD3KCNA3HTR2AHRH1 | |
| SCHEMBL3082500 | 0.87 | DRD3 (0.42) | DRD2DRD3HTR2AHRH1CCR3 | |
| SCHEMBL3082496 | 0.87 | DRD3 (0.42) | DRD2DRD3HTR2AHRH1CCR3 | |
| SCHEMBL3083297 | 0.87 | DRD3 (0.47) | DRD2DRD3HTR2AHRH1CCR3 | |
| SCHEMBL3091198 | 0.87 | DRD3 (0.47) | DRD2DRD3HTR2AHRH1CCR3 | |
| SCHEMBL14715609 | 0.87 | HRH1 (0.45) | DRD2DRD3HTR2AHRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7795437-B2 | Ether derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-09-14 | — | — | US | disclosed |