Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 17/20 | 0.68 |
| ▸ | JAK2 | O60674 | 14/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26987790 | 1.00 | JAK1 (0.68) | JAK1JAK2KCNH2 | |
| SCHEMBL31347584 | 0.86 | JAK1 (0.53) | JAK1JAK2KCNH2 | |
| SCHEMBL26987232 | 0.86 | JAK1 (0.63) | JAK1JAK2KCNH2 | |
| SCHEMBL30757116 | 0.86 | JAK1 (0.63) | JAK1JAK2KCNH2 | |
| SCHEMBL26993923 | 0.86 | JAK1 (0.63) | JAK1JAK2KCNH2 | |
| SCHEMBL27030747 | 0.85 | JAK1 (0.51) | JAK1JAK2KCNH2 | |
| SCHEMBL30756978 | 0.85 | JAK1 (0.57) | JAK1JAK2KCNH2 | |
| SCHEMBL27141010 | 0.85 | JAK1 (0.57) | JAK1JAK2KCNH2 | |
| SCHEMBL26986876 | 0.85 | JAK1 (0.57) | JAK1JAK2KCNH2 | |
| SCHEMBL31347560 | 0.84 | JAK1 (0.51) | JAK1JAK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | DONG-A ST CO., LTD. (KR) | 2025-03-04 | — | — | US | claimed |
| EP-4551570-A1 | NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | Dong-A ST Co., Ltd. (KR) | 2025-05-14 | — | — | EP | disclosed |
| CN-119403798-A | Novel compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | 东亚ST 株式会社 | 2025-02-07 | — | — | CN | disclosed |
| WO-2024009215-A1 | NOVEL COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | EIF2AK4, GCN1, GCGR | JAK1 4139/4885JAK2 4317/4885KCNH2 4247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.