Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.48 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27833684 | 0.81 | NPC1 (0.45) | CYP1A2NPC1RAB9AALDH1A1TDP1 | |
| SCHEMBL27682796 | 0.79 | CYP1A2 (0.57) | CYP1A2NPC1RAB9AALDH1A1TDP1 | |
| SCHEMBL1263287 | 0.78 | CYP1A2 (0.55) | CYP1A2NPC1RAB9AALDH1A1TDP1 | |
| SCHEMBL9047230 | 0.77 | ALDH1A1 (0.51) | CYP1A2NPC1RAB9AALDH1A1TDP1 | |
| SCHEMBL824005 | 0.77 | PLK1 (0.61) | CYP1A2NPC1RAB9AALDH1A1TDP1 | |
| SCHEMBL13140866 | 0.76 | ABCG2 (0.59) | CYP1A2RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL27740602 | 0.76 | CYP19A1 (0.46) | NPC1RAB9AALDH1A1IDO1MAPT | |
| SCHEMBL27743881 | 0.76 | CYP1A2 (0.59) | CYP1A2NPC1RAB9AALDH1A1IDO1 | |
| SCHEMBL15637445 | 0.75 | PDE4D (0.51) | CYP1A2NPC1RAB9AALDH1A1TDP1 | |
| SCHEMBL4427261 | 0.75 | NPC1 (0.52) | NPC1RAB9AALDH1A1TDP1IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8778919-B2 | Cyclic anilino—pyridinotriazines | JANSSEN PHARMACEUTICA NV (BE) | 2014-07-15 | — | — | US | disclosed |
| CN-101341138-B | Cyclic anilino-pyridinotriazines as GSK-3 inhibitors | JANSSEN PHARMACEUTICA NV | 2012-11-14 | — | — | CN | disclosed |
| US-20100222574-A1 | CYCLIC ANILINO - PYRIDINOTRIAZINES | JANSSEN PHARMACEUTICA N.V. (BE) | 2010-09-02 | — | — | US | disclosed |
| EP-1904461-B1 | CYCLIC ANILINO-PYRIDINOTRIAZINES AS GSK-3 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2009-08-12 | — | — | EP | disclosed |
| CN-101341138-A | Cyclic anilino-pyridinotriazines as GSK-3 inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2009-01-07 | — | — | CN | disclosed |
| EP-1904461-A2 | CYCLIC ANILINOPYRIDINOTRIAZINES AS GSK-3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2008-04-02 | — | — | EP | disclosed |
| WO-2007003525-A2 | CYCLIC ANILINO-PYRIDINOTRIAZINES AS GSK-3 INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222574-A1 | CYCLIC ANILINO - PYRIDINOTRIAZINES | NR4A1, NR4A2, NR5A2 | CYP1A2 68/4885NPC1 1575/4885RAB9A 4414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.