Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 4/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26688940 | 1.00 | EDNRA (0.36) | EDNRAAGTR1POLBHSD17B10ALDH1A1 | |
| SCHEMBL26688792 | 0.92 | EDNRA (0.36) | EDNRAAGTR1POLBHSD17B10MAPT | |
| SCHEMBL30757292 | 0.92 | EDNRA (0.36) | EDNRAAGTR1POLBHSD17B10MAPT | |
| SCHEMBL534996 | 0.90 | EDNRA (0.43) | EDNRAAGTR1EDNRB | |
| SCHEMBL30757507 | 0.89 | NPC1 (0.36) | EDNRAAGTR1POLBHSD17B10ALDH1A1 | |
| SCHEMBL26688997 | 0.89 | NPC1 (0.36) | EDNRAAGTR1POLBHSD17B10ALDH1A1 | |
| SCHEMBL5534772 | 0.88 | EDNRA (0.35) | EDNRAAGTR1MAPTEDNRB | |
| SCHEMBL5530422 | 0.85 | EDNRA (0.38) | EDNRAAGTR1 | |
| SCHEMBL5531210 | 0.84 | EDNRA (0.41) | EDNRAAGTR1EDNRB | |
| SCHEMBL30171097 | 0.84 | EDNRA (0.41) | EDNRAAGTR1EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |