Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.51 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7276820 | 1.00 | CNKSR1 (0.51) | CNKSR1DPP4TTRCA12CA1 | |
| SCHEMBL12083630 | 0.77 | CNKSR1 (0.51) | CNKSR1DPP4TTRCA12CA1 | |
| SCHEMBL3179969 | 0.74 | NOS3 (0.39) | — | |
| SCHEMBL13304571 | 0.72 | CNKSR1 (0.48) | CNKSR1DPP4TTRCA12CA1 | |
| SCHEMBL16750522 | 0.70 | CA12 (0.48) | CNKSR1DPP4TTRCA12CA1 | |
| SCHEMBL14370627 | 0.69 | CNKSR1 (0.54) | CNKSR1DPP4TTRCA12CA1 | |
| SCHEMBL29155777 | 0.68 | CNKSR1 (0.51) | CNKSR1DPP4TTRCA12CA1 | |
| SCHEMBL29830043 | 0.68 | CNKSR1 (0.51) | CNKSR1DPP4TTRCA12CA1 | |
| SCHEMBL15811519 | 0.68 | CNKSR1 (1.00) | CNKSR1DPP4TTRCA12CA1 | |
| SCHEMBL2775389 | 0.67 | CA12 (0.51) | CNKSR1DPP4TTRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023224963-A1 | DUAL-ACTING ANGIOTENSIN AND ENDOTHELIN RECEPTOR ANTAGONISTS | ARIA PHARMACEUTICALS, INC. (US) | 2023-11-23 | — | — | WO | disclosed |