Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | RXRB | P28702 | 1/20 | 0.33 |
| ▸ | RXRG | P48443 | 1/20 | 0.33 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.31 |
| ▸ | ATR | Q13535 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30922452 | 0.92 | RXRA (0.35) | RXRARXRBRXRGDGAT2 | |
| SCHEMBL30923075 | 0.92 | KRAS (0.34) | KRASRXRARXRBRXRGUSP30 | |
| SCHEMBL30923128 | 0.91 | RXRA (0.34) | RXRARXRBRXRGDGAT2HTR4 | |
| SCHEMBL30922645 | 0.89 | RXRA (0.39) | RXRARXRBRXRGDGAT2 | |
| SCHEMBL30922742 | 0.86 | RXRA (0.35) | RXRARXRBRXRGDGAT2 | |
| SCHEMBL30922623 | 0.85 | RXRA (0.31) | KRASRXRARXRBRXRGDGAT2 | |
| SCHEMBL30759031 | 0.85 | RXRA (0.36) | KRASRXRARXRBRXRGDGAT2 | |
| SCHEMBL31691654 | 0.84 | USP30 (0.38) | KRASUSP30 | |
| SCHEMBL30922972 | 0.84 | RXRA (0.31) | KRASRXRARXRBRXRGDGAT2 | |
| SCHEMBL30922504 | 0.83 | CYP4F2 (0.35) | RXRARXRBRXRGHTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4573095-A1 | PYRIDOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2025-06-25 | — | — | EP | disclosed |
| WO-2024040131-A1 | PYRIDOPYRIMIDINE KRAS INHIBITORS | Treeline Biosciences, Inc. (US) | 2024-02-22 | — | — | WO | disclosed |