SCHEMBL30759547

SCHEMBL30759547

COc1cc2c(cc1-c1cncc(C(N)=O)c1)-c1c(c(C(=O)N3CCOCC3(C)C)nn1-c1cc(Cl)cc(Cl)c1)CC2

nearest known ligand 0.34

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ GRM5 P41594 2/20 0.34
▸ IKBKB O14920 11/20 0.34
▸ PIK3CD O00329 4/20 0.32
▸ PIK3R2 O00459 4/20 0.32
▸ PIK3CA P42336 4/20 0.32
▸ PIK3CB P42338 4/20 0.32
▸ PIK3CG P48736 4/20 0.32
▸ PIK3R5 Q8WYR1 4/20 0.32
▸ PIK3R3 Q92569 4/20 0.32
▸ CCNA2 P20248 1/20 0.32
▸ CDK2 P24941 1/20 0.32
▸ CCNA1 P78396 1/20 0.32
▸ RAD52 P43351 1/20 0.31
▸ GABRA5 P31644 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27117594 1.00 GRM5 (0.34) GRM5IKBKBPIK3CDPIK3R2PIK3CA
SCHEMBL27123170 0.96 IKBKB (0.36) GRM5IKBKBPIK3CDPIK3R2PIK3CA
SCHEMBL27118847 0.95 GRM5 (0.34) GRM5IKBKBPIK3CDPIK3R2PIK3CA
SCHEMBL27120416 0.93 IKBKB (0.33) IKBKBCCNA2CDK2CCNA1RAD52
SCHEMBL27123503 0.93 IKBKB (0.37) GRM5IKBKBPIK3CDPIK3R2PIK3CA
SCHEMBL27123995 0.92 IKBKB (0.34) GRM5IKBKBPIK3CDPIK3R2PIK3CA
SCHEMBL27124148 0.92 IKBKB (0.37) IKBKBPIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL27123489 0.92 PIK3CD (0.41) IKBKBPIK3CDPIK3R2PIK3CAPIK3CB
SCHEMBL31236998 0.91 GRM5 (0.35) GRM5
SCHEMBL30759659 0.91 IKBKB (0.36) GRM5IKBKBPIK3CDPIK3R2PIK3CA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF GEDEON RICHTER PLC (HU) 2026-01-08 — — US disclosed
EP-4577206-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF Celmatix Inc. (US) 2025-07-02 — — EP disclosed
WO-2024044778-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF CELMATIX INC. (US) 2024-02-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF FSHR, GNRHR, LHCGR GRM5 222/4885IKBKB 660/4885PIK3CD 2697/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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