SCHEMBL30759614

SCHEMBL30759614

COc1cc2c(cc1Br)-c1c(c(C(=O)N3CCOCC3(C)C)nn1-c1ccsc1)CC2

nearest known ligand 0.36

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 15/20 0.36
▸ PIK3R2 O00459 15/20 0.36
▸ PIK3CA P42336 15/20 0.36
▸ PIK3CB P42338 15/20 0.36
▸ PIK3CG P48736 15/20 0.36
▸ PIK3R5 Q8WYR1 15/20 0.36
▸ PIK3R3 Q92569 15/20 0.36
▸ UGCG Q16739 1/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ TP53 P04637 1/20 0.33
▸ MAPK1 P28482 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ GLA P06280 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ GRM5 P41594 1/20 0.33
▸ PDE7A Q13946 1/20 0.32
▸ PDE3A Q14432 1/20 0.32
▸ PDE10A Q9Y233 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27122795 1.00 PIK3CD (0.36) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL27119088 0.95 PIK3CD (0.37) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL17783226 0.88 PIK3CD (0.36) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL30759592 0.87 GRM5 (0.38) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL27119377 0.87 GRM5 (0.38) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL27123561 0.87 GRM5 (0.36) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL30759609 0.87 GRM5 (0.36) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL30759666 0.85 IKBKB (0.33) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL27122692 0.85 IKBKB (0.33) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG
SCHEMBL30759626 0.84 PIK3CD (0.41) PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF GEDEON RICHTER PLC (HU) 2026-01-08 — — US disclosed
EP-4577206-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF Celmatix Inc. (US) 2025-07-02 — — EP disclosed
WO-2024044778-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF CELMATIX INC. (US) 2024-02-29 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF FSHR, GNRHR, LHCGR PIK3CD 2697/4885PIK3R2 1155/4885PIK3CA 2950/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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