Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 4/20 | 0.46 |
| ▸ | CCNC | P24863 | 2/20 | 0.43 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PRKCG | P05129 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | PRKX | P51817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30760043 | 1.00 | MAPK1 (0.46) | MAPK1CCNCCDK8DPP4RPS6KA3 | |
| SCHEMBL30760322 | 0.81 | DPP4 (0.60) | CCNCCDK8DPP4RPS6KA3MAP4K4 | |
| SCHEMBL21202128 | 0.79 | GRM4 (0.51) | MAPK1CCNCCDK8RPS6KA3CHEK1 | |
| SCHEMBL13310660 | 0.78 | RPS6KA3 (0.43) | MAPK1CCNCCDK8RPS6KA3CHEK1 | |
| SCHEMBL30760076 | 0.76 | MAPK1 (0.60) | MAPK1CCNCCDK8RPS6KA3CHEK1 | |
| SCHEMBL25660590 | 0.75 | SIRT3 (0.38) | MAPK1CCNCCDK8RPS6KA3SIRT3 | |
| SCHEMBL25301558 | 0.74 | CCNC (0.46) | MAPK1CCNCCDK8RPS6KA3GRM4 | |
| SCHEMBL30522564 | 0.74 | CCNC (0.46) | MAPK1CCNCCDK8RPS6KA3GRM4 | |
| SCHEMBL30760303 | 0.74 | HDAC4 (0.47) | MAPK1CLK4TDP1ABL1 | |
| SCHEMBL13347733 | 0.74 | RPS6KA3 (0.51) | MAPK1CCNCCDK8RPS6KA3CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024040080-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2024-02-22 | — | — | WO | disclosed |