Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 7/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 12/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 8/20 | 0.49 |
| ▸ | RPS6KA5 | O75582 | 3/20 | 0.49 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.49 |
| ▸ | PRKACA | P17612 | 3/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 3/20 | 0.49 |
| ▸ | AKT1 | P31749 | 3/20 | 0.49 |
| ▸ | AKT2 | P31751 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 3/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | PRKX | P51817 | 3/20 | 0.49 |
| ▸ | NEK4 | P51957 | 3/20 | 0.49 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.49 |
| ▸ | PRKG2 | Q13237 | 3/20 | 0.49 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.49 |
| ▸ | PKN2 | Q16513 | 3/20 | 0.49 |
| ▸ | CDC42BPA | Q5VT25 | 3/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.49 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3104408 | 0.85 | MAPK1 (0.67) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30760184 | 0.84 | MAPK1 (0.51) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL3093972 | 0.78 | MAPK1 (0.73) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30760160 | 0.78 | MAPK1 (0.46) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30760039 | 0.78 | MAPK1 (0.46) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL16679599 | 0.76 | MAPK1 (1.00) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL19813035 | 0.76 | MAPK1 (1.00) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 | |
| SCHEMBL30760043 | 0.76 | MAPK1 (0.46) | MAPK1ROCK1RPS6KA5MAP4K4PRKACA | |
| SCHEMBL30760149 | 0.76 | MAPK1 (0.46) | MAPK1ROCK1RPS6KA5MAP4K4PRKACA | |
| SCHEMBL3106386 | 0.74 | MAPK1 (0.57) | MAPK1ROCK2ROCK1RPS6KA5MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024040080-A1 | KRAS INHIBITOR CONJUGATES | ERASCA, INC. (US) | 2024-02-22 | — | — | WO | disclosed |