Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 4/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 4/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30760415 | 0.88 | FYN (0.39) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL26146265 | 0.82 | PIK3CD (0.42) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL30760475 | 0.82 | JAK1 (0.39) | JAK2JAK1TYK2JAK3PIM1 | |
| SCHEMBL30760460 | 0.80 | IKBKE (0.42) | — | |
| SCHEMBL30363245 | 0.79 | USP30 (0.54) | CHEK1PIM1PIM2USP30 | |
| SCHEMBL25415913 | 0.77 | CHEK1 (0.42) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29674063 | 0.77 | CHEK1 (0.42) | CHEK1JAK2JAK1TYK2JAK3 | |
| SCHEMBL25416871 | 0.76 | RET (0.42) | BTKRET | |
| SCHEMBL30760335 | 0.75 | PDGFRA (0.47) | STING1FYNUSP30CREBBP | |
| SCHEMBL17438060 | 0.74 | PIM1 (0.47) | CHEK1STING1MAP4K4PIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247595-A1 | PYRAZOLOPYRAZINE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |